Control of Gene Expression by Oligonucleoside Methylphosphonates
Identifieur interne : 004E16 ( Main/Exploration ); précédent : 004E15; suivant : 004E17Control of Gene Expression by Oligonucleoside Methylphosphonates
Auteurs : Paul S. Miller [États-Unis] ; Cheryl H. Agris [États-Unis] ; Laure Aurelian [États-Unis] ; Kathleen R. Blake [États-Unis] ; Shwu-Bin Lin [États-Unis] ; Akira Murakami [États-Unis] ; M. Parameswara Reddy [États-Unis] ; Cynthia Smith [États-Unis] ; Paul O. P. Ts [États-Unis]Source :
- The Jerusalem Symposia on Quantum Chemistry and Biochemistry [ 0924-4875 ]
Abstract
Abstract: A major goal in understanding the processes of aging, cancer and differentiation is to understand gene expression and thus the function of various proteins in the overall biochemical processes of the cell. One of the classical ways to study gene expression is through the use of temperature sensitive mutants. Although this approach has been particularly effective in studying gene expression in bacteria and viruses, it is technically more difficult in eukaryotes, particularly mammalian cells. It would be desirable to have an alternative approach which would allow selective inhibition of gene expression either at the level of transcription or at the mRNA level. Recent studies have shown that such regulation may be achieved through the use of complementary DNAs (cDNAs) or anti-sense RNAs. The expression of mRNA can be regulated both in the test tube and in cells by cDNAs which selectively hybridize to a target mRNA. Control of cell-free mRNA translation in this manner is termed hybridization arrest (1). This procedure has been used to study the location and arrangement of adenovirus 2 genes within the viral genome and to analyze mRNA populations in mouse liver (2). Hybridization arrest has also been used to study the function of the 3′-non-coding region of globin mRNA (3).
Url:
DOI: 10.1007/978-94-009-5466-3_21
Affiliations:
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Ts</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biophysics, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="s" type="main" xml:lang="en">The Jerusalem Symposia on Quantum Chemistry and Biochemistry</title><idno type="ISSN">0924-4875</idno><idno type="ISSN">0924-4875</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0924-4875</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A major goal in understanding the processes of aging, cancer and differentiation is to understand gene expression and thus the function of various proteins in the overall biochemical processes of the cell. One of the classical ways to study gene expression is through the use of temperature sensitive mutants. Although this approach has been particularly effective in studying gene expression in bacteria and viruses, it is technically more difficult in eukaryotes, particularly mammalian cells. It would be desirable to have an alternative approach which would allow selective inhibition of gene expression either at the level of transcription or at the mRNA level. Recent studies have shown that such regulation may be achieved through the use of complementary DNAs (cDNAs) or anti-sense RNAs. The expression of mRNA can be regulated both in the test tube and in cells by cDNAs which selectively hybridize to a target mRNA. Control of cell-free mRNA translation in this manner is termed hybridization arrest (1). This procedure has been used to study the location and arrangement of adenovirus 2 genes within the viral genome and to analyze mRNA populations in mouse liver (2). Hybridization arrest has also been used to study the function of the 3′-non-coding region of globin mRNA (3).</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>College Park (Maryland)</li></settlement><orgName><li>Université du Maryland</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Miller, Paul S" sort="Miller, Paul S" uniqKey="Miller P" first="Paul S." last="Miller">Paul S. Miller</name></region><name sortKey="Agris, Cheryl H" sort="Agris, Cheryl H" uniqKey="Agris C" first="Cheryl H." last="Agris">Cheryl H. Agris</name><name sortKey="Aurelian, Laure" sort="Aurelian, Laure" uniqKey="Aurelian L" first="Laure" last="Aurelian">Laure Aurelian</name><name sortKey="Blake, Kathleen R" sort="Blake, Kathleen R" uniqKey="Blake K" first="Kathleen R." last="Blake">Kathleen R. Blake</name><name sortKey="Lin, Shwu Bin" sort="Lin, Shwu Bin" uniqKey="Lin S" first="Shwu-Bin" last="Lin">Shwu-Bin Lin</name><name sortKey="Murakami, Akira" sort="Murakami, Akira" uniqKey="Murakami A" first="Akira" last="Murakami">Akira Murakami</name><name sortKey="Reddy, M Parameswara" sort="Reddy, M Parameswara" uniqKey="Reddy M" first="M. Parameswara" last="Reddy">M. Parameswara Reddy</name><name sortKey="Smith, Cynthia" sort="Smith, Cynthia" uniqKey="Smith C" first="Cynthia" last="Smith">Cynthia Smith</name><name sortKey="Ts, Paul O P" sort="Ts, Paul O P" uniqKey="Ts P" first="Paul O. P." last="Ts">Paul O. P. Ts</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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